Which enzyme in the skin is up-regulated by inflammation, ageing and UV exposure?

And the answer is… cholesterol sulfotransferase! This enzyme catalyzes the sulfation reaction of cholesterol, making it more water-soluble. The negative effects of this reaction in the skin are hyperkeratinisation, decreased desquamation and impaired skin barrier function. Desultine, launched by Contipro, is a hexapeptide which inhibits the enzyme. In vivo studies have proven pigment reduction (age spots), reduced TEWL and improved elasticity.